Binding of Ras to PI3K: Measuring Binding Affinity, and the Effects of Disease-Linked H-Ras Mutations on Affinity
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چکیده
منابع مشابه
the effects of planning on accuracy and complexity of iranian efl students’ written narrative task performance
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15 صفحه اولBinding Affinity of Antibodies?
Although the switch process is frequently associated with affinity maturation, the constant region is not assumed to play a role in Ag–Ab binding. In the present work, we demonstrate that two clonally related human monoclonal Igs sharing identical V H and V L sequences, but expressing different isotypes (IgA1 k PER and IgG1 k PER ), bind tubulin with significantly different affinities. This dif...
متن کاملEvidence for a high affinity, saturable, prenylation-dependent p21Ha-ras binding site in plasma membranes.
Oncogenic p21ras proteins can only exert their stimulation of cellular proliferation when plasma membrane-associated. This membrane association has an absolute requirement for post-translational modification with isoprenoids. The mechanism by which isoprenoids participate in the specific association of p21ras with plasma membranes is the subject of this report. We present in vitro evidence for ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.1610